Tyrell was awarded a BSc in Molecular Biology from the University of Wyoming in 2010, completing an undergraduate research project entitled “Development of magnetic cell isolation from microbial communities in natural samples”. The same year Tyrell achieved a BSc in Electrical Engineering (bioengineering focus) from the University of Wyoming after completing a senior design project “Microfluidic PCR machine with electrowetting”. From 2010 to 2012 Tyrell completed a MSc, also at the University of Wyoming, completing a thesis under the title “Acanthamoeba castellanii feeding decisions as a predictor of bacterial virulence”. His experience working with Acanthamoeba led Tyrell to a strong interest in physiologically relevant quantitative phase imaging and computational microscopy, and from 2012-1014 he pursued independent projects in this area before joining the PHOQUS cohort in 2014.
Role in the Project
Tyrell joined the University of Dundee as a Marie Curie ESR fellow on the PHOtonic tools for Quantitative imaging in tissUeS (PHOQUS) project in August 2014. Tyrell’s project involves the use of optical trapping to reconstitute and examine the mechanical properties of the kinetochore / microtubule interface involved in cell division. Tyrell is developing a bespoke optical trapping and computational imaging microscope to investigate the KT/MT interface to generate insight into how forces in cells are transduced to control precise mechanical operations. Tyrell is supervised by Prof. Tomoyuki Tanaka and Dr. David McGloin.
Tyrell has two projects in computational optics for microscopy, suitable for an advanced undergraduate student. Students interested in contributing to these projects should read the descriptions below for more information:
Journal and Conference Papers and Posters
[November 2017] Transport of intensity equation microscopy for dynamic microtubules, arXiv preprint arXiv:1707.04139,
[August 2016] Catching the perfect wavelet: multi-resolution signal analysis for biophysics. Oral presentation at the Biophotonic approaches: From molecules to living systems conference, Dundee, Scotland, 23rd August 2016.